Grid Structure

I made these grids but they are the same on both sides which is not interesting and would lose an audience right away from the lack of attention grabbing structure. I am having trouble coming up with a flexible grid structure. I havent used grids in a long time and at that it was very little. I usually just go at it and throw out guidelines and go from there but I am trying to come up with something that works for the entire annual. Something that can be easily adapted to the next spread